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Article

Phenotypic consequences of purine nucleotide imbalance in Saccharomyces cerevisiae.

Genetics - 1 Oct 2009

Saint-Marc Christelle, Pinson Benoît, Coulpier Fanny, Jourdren Laurent, Lisova Olesia, Daignan-Fornier Bertrand

Abstract excerpt

Coordinating homeostasis of multiple metabolites is a major task for living organisms, and complex interconversion pathways contribute to achieving the proper balance of metabolites. AMP deaminase (AMPD) is such an interconversion enzyme that allows IMP synthesis from AMP. In this article, we show that, under specific conditions, lack of AMPD activity impairs growth. Under these conditions, we found that the...

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Identifiers

PMID: 19635936
DOI: 10.1534/genetics.109.105858
PMCID: PMC2766314

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