Article
Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses.
Science (New York, N.Y.) - 20 Nov 1998
Thresher R J, Vitaterna M H, Miyamoto Y, Kazantsev A, Hsu D S, Petit C, Selby C P, Dawut L, Smithies O, Takahashi J S, Sancar A
Abstract excerpt
Cryptochromes are photoactive pigments in the eye that have been proposed to function as circadian photopigments. Mice lacking the cryptochrome 2 blue-light photoreceptor gene (mCry2) were tested for circadian clock-related functions. The mutant mice had a lower sensitivity to acute light induction of mPer1 in the suprachiasmatic nucleus (SCN) but exhibited normal circadian oscillations of mPer1 and mCry1...
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