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Article

The role of p53 in megakaryocyte differentiation and the megakaryocytic leukemias of Down syndrome.

Cancer genetics and cytogenetics - 1 Jan 2000

Malkin D, Brown E J, Zipursky A

Abstract excerpt

Sequence analysis of the p53 tumor suppressor gene was performed on diagnostic blood and bone marrow samples from nine children with Down syndrome and acute megakaryoblastic leukemia. p53 sequence alterations were not observed in any of seven cases of transient leukemia; however, samples from two of three patients with acute megakaryoblastic leukemia harbored sequence alterations. The acquisition of both...

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PMID: 10616523
DOI: 10.1016/s0165-4608(99)00072-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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