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Article

Risk for leukemia in infants without Down syndrome who have transient myeloproliferative disorder.

The Journal of pediatrics - 1 May 2006

Cushing Thomas, Clericuzio Carol L, Wilson Carla S, Taub Jeffrey W, Ge Yubin, Reichard Kaaren K, Winter Stuart S

Abstract excerpt

Transient myeloproliferative disorder (TMD) occurs in 10% of infants with Down syndrome (DS). Down syndrome infants with resolved TMD may later develop acute megakaryocytic leukemia (AMKL). In these patients, AMKL is associated with somatic mutations in the X-linked transcription factor gene, GATA1. AMKL also has been described after TMD in children without DS. We report on a non-DS child identified with trisomy...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Leukemia, Megakaryoblastic, Acute

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Source

Identifiers

PMID: 16737888
DOI: 10.1016/j.jpeds.2005.12.031

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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