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Article

GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome.

Blood - 1 Jun 2003

Hitzler Johann K, Cheung Joseph, Li Yue, Scherer Stephen W, Zipursky Alvin

Abstract excerpt

Children with constitutional trisomy 21 (Down syndrome) have an approximately 500-fold increased risk of developing acute megakaryoblastic leukemia (AMKL), a form of acute myeloid leukemia. Unique to newborn infants with Down syndrome is a transient leukemia (TL), also referred to as transient myeloproliferative syndrome, that undergoes spontaneous remission in the majority of cases but in approximately 20% is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12586620
DOI: 10.1182/blood-2003-01-0013

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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