Article
Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome.
Blood - 15 Oct 2003
Xu Gang, Nagano Masumi, Kanezaki Rika, Toki Tsutomu, Hayashi Yasuhide, Taketani Takeshi, Taki Tomohiko, Mitui Tetsuo, Koike Kenichi, Kato Koji, Imaizumi Masue, Sekine Isao, Ikeda Yasuhiko, Hanada Ryoji, Sako Masahiro, Kudo Kazuko, Kojima Seiji, Ohneda Osamu, Yamamoto Masayuki, Ito Etsuro
Abstract excerpt
Transient myeloproliferative disorder (TMD) is a leukemoid reaction occurring occasionally in Down syndrome newborn infants. Acute megakaryocytic leukemia (AMKL) develops in approximately 20% to 30% of the cases with TMD. Recently, acquired mutations in the N-terminal activation domain of the GATA-1 gene, encoding the erythroid/megakaryocytic transcription factor GATA-1, have been reported in Down...
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