Article
Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome.
British journal of haematology - 1 May 2008
Sato Tomohiko, Toki Tsutomu, Kanezaki Rika, Xu Gang, Terui Kiminori, Kanegane Hirokazu, Miura Masayoshi, Adachi Souichi, Migita Masahiro, Morinaga Shingo, Nakano Takahide, Endo Mikiya, Kojima Seiji, Kiyoi Hitoshi, Mano Hiroyuki, Ito Etsuro
Abstract excerpt
JAK3 mutations have been reported in transient myeloproliferative disorder (TMD) as well as in acute megakaryoblastic leukaemia of Down syndrome (DS-AMKL). However, functional consequences of the JAK3 mutations in TMD patients remain undetermined. To further understand how JAK3 mutations are involved in the development and/or progression of leukaemia in Down syndrome, additional TMD patients and the DS-AMKL cell...
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