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Article

Development of acute megakaryoblastic leukemia from a minor clone in a Down syndrome patient with clinically overt transient myeloproliferative disorder.

Journal of pediatric hematology/oncology - 1 Oct 2006

Xu Gang, Kato Koji, Toki Tsutomu, Takahashi Yoshihiro, Terui Kiminori, Ito Etsuro

Abstract excerpt

A Down syndrome male showed leukocytosis from birth and was diagnosed as transient myeloproliferative disorder (TMD). Eight months later, his condition had progressed to myelodysplastic syndrome after spontaneous resolution, and it then evolved to acute megakaryoblastic leukemia (AMKL) at the age of 20 months. Sequencing analysis showed that the predominant TMD and AMKL clones had different GATA1 mutations,...

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Source

Identifiers

PMID: 17023834
DOI: 10.1097/01.mph.0000212997.02554.f6

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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