Article
Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function.
Neuroscience - 1 Jan 1999
Paradee W, Melikian H E, Rasmussen D L, Kenneson A, Conn P J, Warren S T
Abstract excerpt
Fragile X syndrome is an X-linked form of mental retardation resulting from the absence of expression of the fragile X mental retardation 1 gene. The encoded protein is a ribosome-associated, RNA-binding protein thought to play a role in translational regulation of selective messenger RNA transcripts. A knockout mouse has been described that exhibits subtle deficits in spatial learning but normal early-phase...
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