Article
Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice.
Neurobiology of disease - 1 Dec 2016
Yau S Y, Bostrom C A, Chiu J, Fontaine C J, Sawchuk S, Meconi A, Wortman R C, Truesdell E, Truesdell A, Chiu C, Hryciw B N, Eadie B D, Ghilan M, Christie B R
Abstract excerpt
Fragile-X syndrome (FXS) is caused by the transcriptional repression of the Fmr1 gene resulting in loss of the Fragile-X mental retardation protein (FMRP). This leads to cognitive impairment in both male and female patients, however few studies have focused on the impact of FXS in females. Significant cognitive impairment has been reported in approximately 35% of women who exhibit a heterozygous Fmr1 gene...
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