Article
A phenotypic and molecular characterization of the fmr1-tm1Cgr fragile X mouse.
Genes, brain, and behavior - 1 Dec 2004
Yan Q J, Asafo-Adjei P K, Arnold H M, Brown R E, Bauchwitz R P
Abstract excerpt
Fragile X Syndrome is the most common form of inherited mental retardation. It is also known for having a substantial behavioral morbidity, including autistic features. In humans, Fragile X Syndrome is almost always caused by inactivation of the X-linked FMR1 gene. A single knockout mouse model, fmr1-tm1Cgr, exists. In this report we further characterize the cognitive and behavioral phenotype of the fmr1-tm1Cgr...
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