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Article

Altered synaptic plasticity in a mouse model of fragile X mental retardation.

Proceedings of the National Academy of Sciences of the United States of America - 28 May 2002

Huber Kimberly M, Gallagher Sean M, Warren Stephen T, Bear Mark F

Abstract excerpt

Fragile X syndrome, the most common inherited form of human mental retardation, is caused by mutations of the Fmr1 gene that encodes the fragile X mental retardation protein (FMRP). Biochemical evidence indicates that FMRP binds a subset of mRNAs and acts as a regulator of translation. However, the consequences of FMRP loss on neuronal function in mammals remain unknown. Here we show that a form of protein...

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Share to Fragile X Mental Retardation Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12032354
DOI: 10.1073/pnas.122205699
PMCID: PMC124340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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