Article
Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa.
Proceedings of the National Academy of Sciences of the United States of America - 21 Dec 1999
Darby C, Cosma C L, Thomas J H, Manoil C
Abstract excerpt
Identification of host factors that interact with pathogens is crucial to an understanding of infectious disease, but direct screening for host mutations to aid in this task is not feasible in mammals. The nematode Caenorhabditis elegans is a genetically tractable alternative for investigating the pathogenic bacterium Pseudomonas aeruginosa. A P. aeruginosa toxin, produced at high cell density under control of...
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