Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.

PLoS pathogens - 26 Aug 2010

Shao Zhiyong, Zhang Yi, Ye Qi, Saldanha Jenifer Neeta, Powell-Coffman Jo Anne

Abstract excerpt

Pseudomonas aeruginosa is a nearly ubiquitous human pathogen, and infections can be lethal to patients with impaired respiratory and immune systems. Prior studies have established that strong loss-of-function mutations in the egl-9 gene protect the nematode C. elegans from P. aeruginosa PAO1 fast killing. EGL-9 inhibits the HIF-1 transcription factor via two pathways. First, EGL-9 is the enzyme that targets HIF-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoblotting

Share to Immunoprecipitation

Share to Pseudomonas aeruginosa

Share to Pseudomonas Infections

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 20865124
DOI: 10.1371/journal.ppat.1001075
PMCID: PMC2928816

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.PMID 20865124Read ↗

The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1.Semantic proximity Read ↗

Crosstalk in oxygen homeostasis networks: SKN-1/NRF inhibits the HIF-1 hypoxia-inducible factor in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.Semantic proximity Read ↗

Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death.Semantic proximity Read ↗

Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa.Semantic proximity Read ↗

Genetic analysis of hypoxia signaling and response in C elegans.Semantic proximity Read ↗

Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.Semantic proximity Read ↗

Multiparameter behavioral analyses provide insights to mechanisms of cyanide resistance in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans.Semantic proximity Read ↗

A HIF-independent mediator of transcriptional responses to oxygen deprivation in Caenorhabditis elegans.Semantic proximity Read ↗

An essential role for XBP-1 in host protection against immune activation in C. elegans.Semantic proximity Read ↗

Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.