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Article

Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans.

The Journal of biological chemistry - 4 Dec 2015

Wu Qiuli, Cao Xiou, Yan Dong, Wang Dayong, Aballay Alejandro

Abstract excerpt

Increasing evidence indicates that immune responses to microbial infections may contribute to neurodegenerative diseases. Here, we show that Pseudomonas aeruginosa infection of Caenorhabditis elegans causes a number of neural changes that are hallmarks of neurodegeneration. Using an unbiased genetic screen to identify genes involved in the control of P. aeruginosa-induced neurodegeneration, we identified mes-1,...

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Identifiers

PMID: 26475858
DOI: 10.1074/jbc.M115.674259
PMCID: PMC4705928

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