Article
Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning.
Journal of bacteriology - 1 Nov 2001
Gallagher L A, Manoil C
Abstract excerpt
In this report we describe experiments to investigate a simple virulence model in which Pseudomonas aeruginosa PAO1 rapidly paralyzes and kills the nematode Caenorhabditis elegans. Our results imply that hydrogen cyanide is the sole or primary toxic factor produced by P. aeruginosa that is responsible for killing of the nematode. Four lines of evidence support this conclusion. First, a transposon insertion...
Topics
- Animals
- Caenorhabditis elegans
- Hydrogen Cyanide
- Multienzyme Complexes
- Mutation
- Oxidoreductases
- Oxidoreductases Acting on CH-NH2 Group Donors
- Phenazines
- Pseudomonas aeruginosa