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Article

Central Role for the XRCC1 BRCT I Domain in Mammalian DNA Single-Strand Break Repair

1 Apr 2002

Abstract excerpt

The DNA single-strand break repair (SSBR) protein XRCC1 is required for genetic stability and for embryonic viability. XRCC1 possesses two BRCA1 carboxyl-terminal (BRCT) protein interaction domains, denoted BRCT I and II. BRCT II is required for SSBR during G(1) but is dispensable for this process during S/G(2) and consequently for cell survival following DNA alkylation. Little is known about BRCT I, but this...

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PMID: 11909950
DOI: 10.1128/mcb.22.8.2556-2563.2002

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Central Role for the XRCC1 BRCT I Domain in Mammalian DNA Single-Strand Break RepairPMID 11909950Read ↗

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