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Article

The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms.

Molecular and cellular biology - 1 Jan 2000

Scott I C, Anson-Cartwright L, Riley P, Reda D, Cross J C

Abstract excerpt

The basic helix-loop-helix (bHLH) transcription factor genes Hand1 and Mash2 are essential for placental development in mice. Hand1 promotes differentiation of trophoblast giant cells, whereas Mash2 is required for the maintenance of giant cell precursors, and its overexpression prevents giant cell differentiation. We found that Hand1 expression and Mash2 expression overlap in the ectoplacental cone and...

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Source

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Identifiers

PMID: 10611232
DOI: 10.1128/MCB.20.2.530-541.2000
PMCID: PMC85124

Genes

HAND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms.PMID 10611232Read ↗

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