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Article

Requirement of the mouse I-mfa gene for placental development and skeletal patterning.

The EMBO journal - 2 Nov 1998

Kraut N, Snider L, Chen C M, Tapscott S J, Groudine M

Abstract excerpt

The bHLH-repressor protein I-mfa binds to MyoD family members, inhibits their activity, and blocks their nuclear import and binding to DNA. In situ hybridization analysis demonstrated that mouse I-mfa was highly expressed in extraembryonic lineages, in the sclerotome, and subsequently within mesenchymal precursors of the axial and appendicular skeleton, before chondrogenesis occurs. Targeted deletion of I-mfa in...

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Identifiers

PMID: 9799236
DOI: 10.1093/emboj/17.21.6276
PMCID: PMC1170953

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