Article
Requirement of the mouse I-mfa gene for placental development and skeletal patterning.
The EMBO journal - 2 Nov 1998
Kraut N, Snider L, Chen C M, Tapscott S J, Groudine M
Abstract excerpt
The bHLH-repressor protein I-mfa binds to MyoD family members, inhibits their activity, and blocks their nuclear import and binding to DNA. In situ hybridization analysis demonstrated that mouse I-mfa was highly expressed in extraembryonic lineages, in the sclerotome, and subsequently within mese...
Topics
- Animals
- Apoptosis
- Basic Helix-Loop-Helix Transcription Factors
- Bone Development
- Bone and Bones
- Cell Differentiation
- DNA-Binding Proteins
- Embryonic and Fetal Development
- Gene Expression Regulation, Developmental
- Gene Targeting
- Genotype
- Helix-Loop-Helix Motifs
- In Situ Hybridization
- In Situ Nick-End Labeling
- Mice
- Mice, Knockout
- Mutation
- Myogenic Regulatory Factors