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HMGB1 regulates autophagy of placental trophoblast through ERK signaling pathway

22 Apr 2024

Abstract excerpt

OBJECTIVE: The purpose of this study is to investigate the role of high mobility group protein B1 (HMGB1) in placental development and fetal growth. METHODS: We employed the Cre-loxP recombination system to establish a placenta-specific HMGB1 knockout mouse model. Breeding HMGB1flox/flox mice with Elf5-Cre mice facilitated the knockout, leveraging Elf5 expression in extra-embryonic ectoderm, ectoplacental cone,...

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PMID: 38647664
DOI: 10.1093/biolre/ioae064

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