Article

Human HAND1 inhibits the conversion of cholesterol to steroids in trophoblasts

2021-08-12

Abstract excerpt

Steroidogenesis from cholesterol in placental trophoblasts is fundamentally involved in the establishment and maintenance of pregnancy. The transcription factor gene heart and neural crest derivatives expressed 1 (Hand1) promotes differentiation of mouse trophoblast giant cells. However, the role of HAND1 in human trophoblasts remains unknown. Here, we report that HAND1 inhibits human trophoblastic progesterone (P...

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Literature Corpus work: cc2bf6d2-44e0-5bdf-9f4c-661fb04367fc
DOI: 10.1016/j.jgg.2021.07.014

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