Article
The association of CD18 alleles with anti-myeloperoxidase subtypes of ANCA-associated systemic vasculitides.
Clinical immunology (Orlando, Fla.) - 1 Jan 2000
Gencik M, Meller S, Borgmann S, Sitter T, Menezes Saecker A M, Fricke H, Epplen J T
Abstract excerpt
Wegener granulomatosis (WG), microscopic polyangiitis (MP), and Churg Strauss syndrome (CSS) are rare systemic autoimmune disorders. Common features are anti-neutrophil cytoplasmic antibodies (ANCA) in patient sera. Whereas WG patients show mainly anti-proteinase 3 ANCA, MP and CSS patients typically present anti-myeloperoxidase (MPO) ANCA. ANCA play an important role in the pathogenesis in the vessel wall by...
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