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Article

Novel SNPs in the CD18 gene validate the association with MPO-ANCA+ vasculitis.

Genes and immunity - 1 Aug 2001

Meller S, Jagiello P, Borgmann S, Fricke H, Epplen J T, Gencik M

Abstract excerpt

Wegener granulomatosis (WG), microscopic polyangiitis (MP), and Churg-Strauss syndrome (CSS) are characterized by the presence of anti-neutrophil cytoplasmic antibodies (ANCA). Anti-myeloperoxidase (MPO)-ANCA are a typical feature of MP and CSS, while anti-proteinase 3 (PRTN3)-ANCA are highly specific for WG. Several reports indicate that ANCA may directly contribute to pathological processes, ie, through an...

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Topics

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Share to Antibodies, Antineutrophil Cytoplasmic
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Share to CD18 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Reproducibility of Results

Share to Serine Endopeptidases

Share to Vasculitis

Source

Identifiers

PMID: 11528520
DOI: 10.1038/sj.gene.6363781

Genes

MPO
PRTN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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