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Article

Evolution of mutation rates: phylogenomic analysis of the photolyase/cryptochrome family.

Molecular biology and evolution - 1 May 2009

Lucas-Lledó José Ignacio, Lynch Michael

Abstract excerpt

Photoreactivation, one of the first DNA repair pathways to evolve, is the direct reversal of premutagenic lesions caused by ultraviolet (UV) irradiation, catalyzed by photolyases in a light-dependent, single-enzyme reaction. It has been experimentally shown that photoreactivation prevents UV mutagenesis in a broad range of species. In the absence of photoreactivation, UV-induced photolesions are repaired by the...

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PMID: 19228922
DOI: 10.1093/molbev/msp029
PMCID: PMC2668831

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