Article
Photorepair of RNA polymerase arrest and apoptosis after ultraviolet irradiation in normal and XPB deficient rodent cells.
Cell death and differentiation - 1 Oct 2002
Chiganças V, Batista L F Z, Brumatti G, Amarante-Mendes G P, Yasui A, Menck C F M
Abstract excerpt
Cyclobutane pyrimidine dimers (CPDs) are directly involved in signaling for UV-induced apoptosis in mammalian cells. Failure to remove these lesions, specially those located at actively expressing genes, is critical, as cells defective in transcription coupled repair have increased apoptotic levels. Thus, the blockage of RNA synthesis by lesions is an important candidate event triggering off active cell death. In...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.