Article
A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome.
Genetic epidemiology - 1 Nov 2010
Boonstra Philip S, Gruber Stephen B, Raymond Victoria M, Huang Shu-Chen, Timshel Susanne, Nilbert Mef, Mukherjee Bhramar
Abstract excerpt
Anticipation, manifested through decreasing age of onset or increased severity in successive generations, has been noted in several genetic diseases. Statistical methods for genetic anticipation range from a simple use of the paired t-test for age of onset restricted to affected parent-child pairs to a recently proposed random effects model which includes extended pedigree data and unaffected family members...
Topics
- Anticipation, Genetic
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Computer Simulation
- DNA Mismatch Repair
- Databases, Genetic
- Female
- Humans
- Male
- Models, Genetic
- Models, Statistical
- Molecular Epidemiology
- Mutation
- Pedigree