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Article

Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA and association with psoriasis vulgaris.

Tissue antigens - 1 Nov 1999

Jenisch S, Koch S, Henseler T, Nair R P, Elder J T, Watts C E, Westphal E, Voorhees J J, Christophers E, Krönke M

Abstract excerpt

Corneodesmosin (CD) is thought to play a key role in corneocyte cohesion, and its proteolysis appears to be a major event in the process of desquamation. Recently it was shown that CD is encoded by the S-gene, which is located approximately 160 kb telomeric of HLA-C. In the present study, the role of CD in the genetics of psoriasis vulgaris was studied in greater detail. The second exon of the CD gene was...

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Identifiers

PMID: 10599883
DOI: 10.1034/j.1399-0039.1999.540501.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA and association with psoriasis vulgaris.PMID 10599883Read ↗

Identification of six novel polymorphisms in the human corneodesmosin gene.Semantic proximity Read ↗

Novel genetic association between the corneodesmosin (MHC S) gene and susceptibility to psoriasis.Semantic proximity Read ↗

S gene (Corneodesmosin) diversity and its relationship to psoriasis; high content of cSNP in the HLA-linked S gene.Semantic proximity Read ↗

Mapping of the major psoriasis-susceptibility locus (PSORS1) in a 70-Kb interval around the corneodesmosin gene (CDSN).Semantic proximity Read ↗

Psoriasis is associated with a SNP haplotype of the corneodesmosin gene (CDSN).Semantic proximity Read ↗

Corneodesmosomes and corneodesmosin: from the stratum corneum cohesion to the pathophysiology of genodermatoses.Semantic proximity Read ↗

Searching for the major histocompatibility complex psoriasis susceptibility gene.Semantic proximity Read ↗

Corneodesmosin (CDSN) gene association with psoriasis vulgaris in Caucasian but not in Japanese populations.Semantic proximity Read ↗

Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.Semantic proximity Read ↗

Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.Semantic proximity Read ↗

Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C.Semantic proximity Read ↗

Corneodesmosin gene: no evidence for PSORS 1 gene in North-eastern Thai psoriasis patients.Semantic proximity Read ↗

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