Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.

Human genetics - 1 Dec 2005

Helms Cynthia, Saccone Nancy L, Cao Li, Daw Jil A Wright, Cao Kai, Hsu Tony M, Taillon-Miller Patricia, Duan Shenghui, Gordon Derek, Pierce Brandon, Ott Jurg, Rice John, Fernandez-Vina Marcelo A, Kwok Pui-Yan, Menter Alan, Bowcock Anne M

Abstract excerpt

Psoriasis is a complex inflammatory disease of the skin affecting 1-2% of the Caucasian population. Associations with alleles from the HLA class I region (now known as PSORS1), particularly HLA-Cw*0602, were described over 20 years ago. However, extensive linkage disequilibrium (LD) within this region has made it difficult to identify the true susceptibility allele from this region. A variety of genes and regions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-C Antigens

Share to Intercellular Signaling Peptides and Proteins

Share to Intracellular Signaling Peptides and Proteins

Share to Proteins

Share to Psoriasis

Share to Regression Analysis

Source

Identifiers

PMID: 16235096
DOI: 10.1007/s00439-005-0048-2

Genes

CDSN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.PMID 16235096Read ↗

Mapping of the major psoriasis-susceptibility locus (PSORS1) in a 70-Kb interval around the corneodesmosin gene (CDSN).Semantic proximity Read ↗

Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C.Semantic proximity Read ↗

Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.Semantic proximity Read ↗

An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element.Semantic proximity Read ↗

Searching for the major histocompatibility complex psoriasis susceptibility gene.Semantic proximity Read ↗

Family-based analysis using a dense single-nucleotide polymorphism-based map defines genetic variation at PSORS1, the major psoriasis-susceptibility locus.Semantic proximity Read ↗

The genetics of psoriasis--selected novelties in 2008.Semantic proximity Read ↗

Characterisation of psoriasis susceptibility locus 6 (PSORS6) in patients with early onset psoriasis and evidence for interaction with PSORS1.Semantic proximity Read ↗

Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus.Semantic proximity Read ↗

Fine mapping of the psoriasis susceptibility gene PSORS1: a reassessment of risk associated with a putative risk haplotype lacking HLA-Cw6.Semantic proximity Read ↗

Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population.Semantic proximity Read ↗

Psoriasis-associated genetic polymorphism in North Indian population in the CCHCR1 gene and in a genomic segment flanking the HLA-C region.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.