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Article

Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.

American journal of human genetics - 1 May 2006

Nair Rajan P, Stuart Philip E, Nistor Ioana, Hiremagalore Ravi, Chia Nicholas V C, Jenisch Stefan, Weichenthal Michael, Abecasis Gonçalo R, Lim Henry W, Christophers Enno, Voorhees John J, Elder James T

Abstract excerpt

Previous studies have narrowed the interval containing PSORS1, the psoriasis-susceptibility locus in the major histocompatibility complex (MHC), to an approximately 300-kb region containing HLA-C and at least 10 other genes. In an effort to identify the PSORS1 gene, we cloned and completely sequenced this region from both chromosomes of five individuals. Two of the sequenced haplotypes were associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16642438
DOI: 10.1086/503821
PMCID: PMC1474031

Genes

CDSN
TCF19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.PMID 16642438Read ↗

Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C.Semantic proximity Read ↗

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Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population.Semantic proximity Read ↗

Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.Semantic proximity Read ↗

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