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Article

Novel genetic association between the corneodesmosin (MHC S) gene and susceptibility to psoriasis.

Human molecular genetics - 1 Jun 1999

Tazi Ahnini R, Camp N J, Cork M J, Mee J B, Keohane S G, Duff G W, di Giovine F S

Abstract excerpt

Psoriasis is an inflammatory skin disease of unknown origin, but with a clear genetic component. The strongest genetic association has been found with the major histocompatibility complex (MHC) region, and specifically between susceptibility to familial early onset psoriasis and human leukocyte antigen (HLA)-Cw6. The basis of this association of the HLA-C locus with disease pathogenesis is, however, not clear,...

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Identifiers

PMID: 10332047
DOI: 10.1093/hmg/8.6.1135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Novel genetic association between the corneodesmosin (MHC S) gene and susceptibility to psoriasis.PMID 10332047Read ↗

S gene (Corneodesmosin) diversity and its relationship to psoriasis; high content of cSNP in the HLA-linked S gene.Semantic proximity Read ↗

Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA and association with psoriasis vulgaris.Semantic proximity Read ↗

Mapping of the major psoriasis-susceptibility locus (PSORS1) in a 70-Kb interval around the corneodesmosin gene (CDSN).Semantic proximity Read ↗

Identification of six novel polymorphisms in the human corneodesmosin gene.Semantic proximity Read ↗

Searching for the major histocompatibility complex psoriasis susceptibility gene.Semantic proximity Read ↗

Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C.Semantic proximity Read ↗

Corneodesmosin (CDSN) gene association with psoriasis vulgaris in Caucasian but not in Japanese populations.Semantic proximity Read ↗

Comparative association analysis reveals that corneodesmosin is more closely associated with psoriasis than HLA-Cw*0602-B*5701 in German families.Semantic proximity Read ↗

The genetic basis of psoriasis.Semantic proximity Read ↗

Genetics of psoriasis and psoriatic arthritis.Semantic proximity Read ↗

Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.Semantic proximity Read ↗

Stronger association with HLA-Cw6 than with corneodesmosin (S-gene) polymorphisms in Swedish psoriasis patients.Semantic proximity Read ↗

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