Article
Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density.
The Journal of clinical endocrinology and metabolism - 1 Jul 1998
Rosen C J, Kurland E S, Vereault D, Adler R A, Rackoff P J, Craig W Y, Witte S, Rogers J, Bilezikian J P
Abstract excerpt
We recently demonstrated that insulin growth factor-I (IGF-I) cosegregates with bone mineral density (BMD) in progenitor crosses of two inbred strains of mice. Additionally, we reported that men with idiopathic osteoporosis (IOM) have low serum IGF-I levels, which can be related to BMD and bone t...
Topics
- Aged
- Alleles
- Bone Density
- Dinucleotide Repeats
- Female
- Gene Frequency
- Genotype
- Humans
- Insulin-Like Growth Factor I
- Male
- Middle Aged
- Phenotype
- Polymorphism, Genetic