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Article

Environmental covariates: effects on the power of sib-pair linkage methods.

Genetic epidemiology - 1 Jan 1999

Mandal D M, Sorant A J, Pugh E W, Marcus S E, Klein A P, Mathias R A, O'Neill J, Temiyakarn L F, Wilson A F, Bailey-Wilson J E

Abstract excerpt

The effect of inclusion of environmental risk factors on the power of sib-pair linkage methods was tested for a qualitative trait. It was found that inclusion of an environmental variable did not increase the power of the Haseman-Elston (H-E) sib-pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H-E and affected-sib-pair tests, even in small samples, when...

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Identifiers

PMID: 10597507
DOI: 10.1002/gepi.13701707105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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