Article
The single-nucleotide polymorphism lottery: how useful are a few common SNPs in identifying disease-associated alleles?
Genetic epidemiology - 1 Jan 2001
Barton A, Chapman P, Myerscough A, Pinel T, Davies N, Worthington J, John S
Abstract excerpt
It has been proposed that using association analysis of single nucleotide polymorphism (SNP) markers in candidate genes may be more successful in identifying disease susceptibility genes for complex diseases. Finding all the SNPs within a candidate gene and genotyping a large case-control cohort is a resource-intensive process. As linkage disequilibrium extends across small regions of the genome, the expectation...
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