Article
Mechanisms of DNA expansion.
Chromosoma - 1 Oct 1995
McMurray C T
Abstract excerpt
Unstable transmission of repeating segments in genes is now recognized as a new class of mutations causing human disease. Genetic instability observed in disease is termed an "expansion mutation" when the mutation is an increase in the copy number of a repeated unit, commonly a di- or trinucleotide. While the expansion mutation is well characterized in disease, the mechanism by which expansion occurs is not...
Topics
- Base Sequence
- DNA Replication
- Gene Conversion
- Genetic Diseases, Inborn
- Humans
- Microsatellite Repeats
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Recombination, Genetic