Article

The selective dynamics of interruptions at short tandem repeats

2025-06-12

Abstract excerpt

Short tandem repeats (STRs) are hotspots of genomic instability that mutate at rates orders of magnitude greater than non-repetitive loci due to frequent replication slippage. Expansions at some STR loci cause Mendelian diseases, while variation at other noncoding loci may affect complex traits, possibly by altering transcription factor occupancy of nearby binding sites. Accordingly, some STRs are inferred to be u...

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Literature Corpus work: 2c9228e6-ede9-58be-a166-09581177ecbf
DOI: 10.1101/2025.06.09.658724

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