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Article

Genetic loci that affect aristolochic acid-induced nephrotoxicity in the mouse.

American journal of physiology. Renal physiology - 1 Jun 2011

Rosenquist Thomas A

Abstract excerpt

Aristolochic acids (AA) are plant-derived nephrotoxins and carcinogens found in traditional medicines and herbal remedies. AA causes aristolochic acid nephropathy (AAN) and is a suspected environmental agent in Balkan endemic nephropathy (BEN) and its associated upper urothelial cancer. Approximately 5-10% of individuals exposed to AA develop renal insufficiency and/or cancer; thus a genetic predisposition to AA...

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Identifiers

PMID: 21429970
DOI: 10.1152/ajprenal.00716.2010
PMCID: PMC3119144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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