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Article

Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones.

Antimicrobial agents and chemotherapy - 1 Oct 1999

Brisse S, Fluit A C, Wagner U, Heisig P, Milatovic D, Verhoef J, Scheuring S, Köhrer K, Schmitz F J

Abstract excerpt

The parC and gyrA genes of 73 ciprofloxacin-resistant and 6 ciprofloxacin-susceptible Enterococcus faecium clinical isolates were partly sequenced. Alterations in ParC and GyrA, possibly in combination with other resistance mechanisms, severely restricted the in vitro activities of the nine quinolones tested. For all isolates, clinafloxacin and sitafloxacin showed the best activities.

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Source

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Identifiers

PMID: 10508034
DOI: 10.1128/AAC.43.10.2513
PMCID: PMC89510

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Source receipt: pubmed, retrieved 7 Sept 2026.

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