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Article

Deleterious Effect of RAS and Evolutionary High-risk TP53 Double Mutation in Colorectal Liver Metastases.

Annals of surgery - 1 May 2019

Chun Yun Shin, Passot Guillaume, Yamashita Suguru, Nusrat Maliha, Katsonis Panagiotis, Loree Jonathan M, Conrad Claudius, Tzeng Ching-Wei D, Xiao Lianchun, Aloia Thomas A, Eng Cathy, Kopetz Scott E, Lichtarge Olivier, Vauthey Jean-Nicolas

Abstract excerpt

OBJECTIVE: To assess the impact of somatic gene mutations on survival among patients undergoing resection of colorectal liver metastases (CLM). BACKGROUND: Patients undergoing CLM resection have heterogeneous outcomes, and accurate risk stratification is necessary to optimize patient selection for surgery. METHODS: Next-generation sequencing of 50 cancer-related genes was performed from primary tumors and/or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28767562
DOI: 10.1097/SLA.0000000000002450
PMCID: PMC7462436

Genes

APC
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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