Article
P53 mutation analysis of colorectal liver metastases: relation to actual survival, angiogenic status, and p53 overexpression.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2005
de Jong Koert P, Gouw Annette S H, Peeters Paul M J G, Bulthuis Marian, Menkema Lorian, Porte Robert J, Slooff Maarten J H, van Goor Harry, van den Berg Anke
Abstract excerpt
PURPOSE: To correlate TP53 mutations with angiogenic status of the tumor and prognosis after liver surgery in patients with colorectal liver metastases and to correlate immunohistochemical staining of p53 protein with TP53 gene mutations. EXPERIMENTAL DESIGN: Tumors of 44 patients with surgically treated colorectal liver metastases were analyzed for (a) TP53 mutations using denaturing gradient gel electrophoresis...
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