Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extrinsic modulation of retinal ganglion cell projections: analysis of the albino mutation in pigmentation mosaic mice.

Developmental biology - 1 Dec 1999

Rice D S, Goldowitz D, Williams R W, Hamre K, Johnson P T, Tan S S, Reese B E

Abstract excerpt

Tyrosinase is a key enzyme involved in the synthesis of melanin in the retinal pigment epithelium (RPE). Mice that are homozygous for the albino allele at the tyrosinase locus have fewer retinal ganglion cells with uncrossed projections at the optic chiasm. To determine the site of the albino gene action we studied the projections of retinal ganglion cells in two types of pigmentation mosaic mice. First, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Albinism
Share to beta-Galactosidase
Share to Chimera

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocytochemistry

Share to Lac Operon

Share to Monophenol Monooxygenase

Share to Pigment Epithelium of Eye

Share to Retinal Ganglion Cells

Source

Identifiers

PMID: 10588862
DOI: 10.1006/dbio.1999.9467

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extrinsic modulation of retinal ganglion cell projections: analysis of the albino mutation in pigmentation mosaic mice.PMID 10588862Read ↗

Genetic control of retinal projections in inbred strains of albino mice.Semantic proximity Read ↗

Influence of tyrosinase levels on pigment accumulation in the retinal pigment epithelium and on the uncrossed retinal projection.Semantic proximity Read ↗

New animal models to study the role of tyrosinase in normal retinal development.Semantic proximity Read ↗

Polygenic disease and retinitis pigmentosa: albinism exacerbates photoreceptor degeneration induced by the expression of a mutant opsin in transgenic mice.Semantic proximity Read ↗

Distinct distal regulatory elements control tyrosinase expression in melanocytes and the retinal pigment epithelium.Semantic proximity Read ↗

Molecular characterization of the mouse tyrosinase gene: pigment cell-specific expression in transgenic mice.Semantic proximity Read ↗

The Tyr (albino) locus of the laboratory mouse.Semantic proximity Read ↗

Variegated expression and delayed retinal pigmentation during development in transgenic mice with a deletion in the locus control region of the tyrosinase gene.Semantic proximity Read ↗

Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation.Semantic proximity Read ↗

Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene.Semantic proximity Read ↗

A distal tyrosinase upstream element stimulates gene expression in neural-crest-derived melanocytes of transgenic mice: position-independent and mosaic expression.Semantic proximity Read ↗

Increased transgene expression by the mouse tyrosinase enhancer is restricted to neural crest-derived pigment cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.