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Article

Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1993

Huang P C, Gaitan A E, Hao Y, Petters R M, Wong F

Abstract excerpt

Photoreceptors of transgenic mice expressing a mutant rhodopsin gene (Pro347-->Ser) slowly degenerate. The mechanism of degeneration was studied by aggregation of embryos of normal and transgenic mice to form chimeras. In these chimeras, mosaicism was observed in the coat color, retinal pigment epithelium, and retina. In the retina, the genotype of adjacent patches of normal and transgenic photoreceptors was...

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Identifiers

PMID: 8378322
DOI: 10.1073/pnas.90.18.8484
PMCID: PMC47381

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