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Article

Correlation of in vivo-resistance to chloroquine and allelic polymorphisms in Plasmodium falciparum isolates from Uganda.

Tropical medicine & international health : TM & IH - 1 Mar 2000

Flüeck T P, Jelinek T, Kilian A H, Adagu I S, Kabagambe G, Sonnenburg F, Warhurst D C

Abstract excerpt

The efficacy of chloroquine in the treatment of uncomplicated falciparum malaria in Africa is heavily compromised by high levels of drug resistance. The occurrence of active site mutations in the Plasmodium falciparum multi drug resistance-gene 1 (pfmdr1) has been associated with development of resistance to chloroquine. This study investigates the occurrence of several mutations at codons 86, 1042 and 1246 of...

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Source

Identifiers

PMID: 10747279
DOI: 10.1046/j.1365-3156.2000.00543.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Correlation of in vivo-resistance to chloroquine and allelic polymorphisms in Plasmodium falciparum isolates from Uganda.PMID 10747279Read ↗

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