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Article

Mechanism of gating and partial agonist action in the glycine receptor.

Cell - 18 Feb 2021

Yu Jie, Zhu Hongtao, Lape Remigijus, Greiner Timo, Du Juan, Lü Wei, Sivilotti Lucia, Gouaux Eric

Abstract excerpt

Ligand-gated ion channels mediate signal transduction at chemical synapses and transition between resting, open, and desensitized states in response to neurotransmitter binding. Neurotransmitters that produce maximum open channel probabilities (Po) are full agonists, whereas those that yield lower than maximum Po are partial agonists. Cys-loop receptors are an important class of neurotransmitter receptors, yet a...

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Share to Cryoelectron Microscopy
Share to gamma-Aminobutyric Acid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33567265
DOI: 10.1016/j.cell.2021.01.026
PMCID: PMC8115384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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