Article
The Glu318Gly mutation of the presenilin-1 gene does not necessarily cause Alzheimer's disease.
Annals of neurology - 1 Dec 1998
Mattila K M, Forsell C, Pirttilä T, Rinne J O, Lehtimäki T, Röyttä M, Lilius L, Eerola A, St George-Hyslop P H, Frey H, Lannfelt L
Abstract excerpt
In early-onset familial Alzheimer's disease (AD) pathogenic mutations have been found in the amyloid precursor protein (APP) gene and in the presenilin (PS)-1 and PS-2 genes. We screened for mutations in these genes in 20 patients with familial AD from the Finnish population. In addition, we samp...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amino Acid Sequence
- Amino Acid Substitution
- Amyloid beta-Protein Precursor
- Apolipoprotein E4
- Apolipoproteins E
- Base Sequence
- Female
- Humans