Article
Presenilin-2 mutation and polymorphism in Japanese Alzheimer disease patients.
Clinica chimica acta; international journal of clinical chemistry - 1 May 1999
Tanimukai H, Tsujio I, Hashimoto R, Kudo T, Kamino K, Shinozaki K, Takeda M
Abstract excerpt
The Asn141Ile mutation of the presenilin 2 gene is responsible for familial early-onset Alzheimer disease found in Volga-German kindreds. However, the genetic influence of presenilin 2 gene on sporadic Alzheimer disease remains unknown. In this study, the frequency of the mutation and genetic association with the presenilin 2 locus were investigated in Japanese sporadic cases. The Asn141Ile mutation was not found...
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