Article
Beta-cell maturation leads to in vitro sensitivity to cytotoxins.
Diabetes - 1 Dec 1999
Nielsen K, Karlsen A E, Deckert M, Madsen O D, Serup P, Mandrup-Poulsen T, Nerup J
Abstract excerpt
Pancreatic beta-cells are more sensitive to several toxins (e.g., streptozotocin, alloxan, cytokines) than the other three endocrine cell types in the islets of Langerhans. Cytokine-induced free radicals in beta-cells may be involved in beta-cell-specific destruction in type 1 diabetes. To investigate if this sensitivity represents an acquired trait during beta-cell maturation, we used two in vitro cultured cell...
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