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Article

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells

13 Nov 2018

Abstract excerpt

Abstract Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used by the research community. However, little is known of their electrophysiological and secretory properties. Here, we monitored parameters that constitute the glucose-triggering pathway of insulin release. Both cell lines respond to glucose (6 and...

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PMID: 30451893
DOI: 10.1038/s41598-018-34743-7

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