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Article

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors.

Nature - 4 Nov 1999

Hu X, Lazar M A

Abstract excerpt

N-CoR and SMRT are transcriptional corepressors that associate with nuclear hormone receptors (NRs) in the absence of ligand. This interaction is the molecular target of differentiation therapy for acute promyelocytic leukaemia, wherein retinoic acid dissociates corepressor from leukaemogenic receptor fusion proteins. Binding of ligand to NRs induces a conformation that attracts coactivator proteins containing an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Thyroid Hormone

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Source

Identifiers

PMID: 10573424
DOI: 10.1038/47069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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