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Article

Functional analyses of an LXXLL motif in nuclear receptor corepressor (N-CoR).

The Journal of steroid biochemistry and molecular biology - 1 Aug 2004

Loinder Kristina, Söderström Mats

Abstract excerpt

Transcriptional repression is a major regulatory mechanism in cell differentiation, organogenesis, and oncogenesis. Two repressors of ligand-dependent transcription factors, nuclear receptor corepressor (N-CoR) and the related protein SMRT were identified as a silencing mediator for thyroid hormone receptor beta and as a silencing mediator for retinoic acid and thyroid hormone receptors, respectively. Nuclear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15336696
DOI: 10.1016/j.jsbmb.2004.04.006

Genes

SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Functional analyses of an LXXLL motif in nuclear receptor corepressor (N-CoR).PMID 15336696Read ↗

An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene.Semantic proximity Read ↗

Biological roles and mechanistic actions of co-repressor complexes.Semantic proximity Read ↗

The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs).Semantic proximity Read ↗

A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein.Semantic proximity Read ↗

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors.Semantic proximity Read ↗

Corepressor SMRT functions as a coactivator for thyroid hormone receptor T3Ralpha from a negative hormone response element.Semantic proximity Read ↗

The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.Semantic proximity Read ↗

PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motifSemantic proximity Read ↗

Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors.Semantic proximity Read ↗

The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes.Semantic proximity Read ↗

Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice.Semantic proximity Read ↗

The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).Semantic proximity Read ↗

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