Article
The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs).
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2000
Webb P, Anderson C M, Valentine C, Nguyen P, Marimuthu A, West B L, Baxter J D, Kushner P J
Abstract excerpt
Unliganded thyroid hormone receptors (TRs) repress transcription through recruitment of corepressors, including nuclear receptor corepressor (N-CoR). We find that N-CoR contains three interaction domains (IDs) that bind to TR, rather than the previously reported two. The hitherto unrecognized ID (ID3) serves as a fully functional TR binding site, both in vivo and in vitro, and may be the most important for TR...
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